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Small nucleolar RNA networks are up-regulated during human anaphylaxisAnaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently no reliable diagnostic test to confirm anaphylaxis in the emergency department.
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Searching for a technology-driven acute rheumatic fever test: the START study protocolThe absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus.
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Protection against maternal infection-associated fetal growth restriction: Proof-of-concept with a microbial-derived immunomodulatorThis study suggests that broad-spectrum protection-of-pregnancy against infection-associated inflammatory stress represents an achievable therapeutic goal
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Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinationsCancer immunotherapy has shown impressive results, but most patients do not respond.
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Identification of genes differentially regulated by vitamin D deficiency that alter lung pathophysiology and inflammation in allergic airways diseaseVitamin D deficiency exacerbates house dust mite-induced inflammation and alterations in lung structure and function
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Pneumococcal conjugate vaccination at birth in a high-risk setting: No evidence for neonatal T-cell toleranceConcerns about the risk of inducing immune deviation-associated "neonatal tolerance" as described in mice have restricted the widespread adoption...
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Michael SerralhaMichael Serralha is a Research Assistant in the Chronobiology and ORIGINS teams at The Kids Research Institute Australia.