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Antisense oligonucleotides are an emerging therapeutic option to treat diseases with known genetic origin. In the age of personalised medicines, antisense oligonucleotides can sometimes be designed to target and bypass or overcome a patient's genetic mutation, in particular those lesions that compromise normal pre-mRNA processing. Antisense oligonucleotides can alter gene expression through a variety of mechanisms as determined by the chemistry and antisense oligomer design.
These data provide novel insights into the functionality of neonatal monocytes at birth
Mining developments are being required to consider how they affect local communities and implement strategies to minimise negative impacts they may be causing
There was a positive relationship between the thickness of the airway smooth muscle layer with airway responsiveness, which was shifted upward in the presence of allergy
Currently, DNA methylation is the most studied epigenetic phenomenon in large populations
Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease.
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Following a youth community forum held in March 2016, The Kids Research Institute Australia established the first Youth Advisory Group to ensure that the research conducted about young people at the Institute, is influenced by young people.
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