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B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell subsets from people with clinically isolated syndrome (CIS) or MS. CD32b expression was highest on post-naive IgM+ B cell subsets in healthy controls. For females with MS or CIS, significantly lower CD32b expression was identified on IgM+ B cell subsets, including naive and IgMhi MZ-like B cells, when compared with control females. Lower CD32b expression on these B cell subsets was associated with detectable anti-Epstein Barr Virus viral capsid antigen IgM antibodies, and higher serum levels of B cell activating factor. To investigate the effects of lower CD32b expression, B cells were polyclonally activated in the presence of IgG immune complexes, with or without a CD32b blocking antibody, and the expression of TNF and IL-10 in B cell subsets was assessed.
We describe two unusual cases of MPE and use DNA methylation analyses to compare their signatures to try and distinguish if these represent a unique subset.
We report on 3 children treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy.
Liana’s story begins nine years ago. It starts with a sore ankle, a fever, a trip to the emergency room and clinic and finally a diagnosis of acute rheumatic fever (ARF).
One of Australia’s leading cancer research centres continues to be powered by parents who decided to fight back. Hard.
Vacation students from logistics and transport company Centurion raised over five thousand dollars for The Kids Research Institute Australia through a series of fundraising activities.
The Opportunity The Communications and Development team implements the Institute's overall communications, marketing and philanthropy strategies, as
Senior Postdoctoral Researcher
CliniKids has won the Allied Health Professionals category at the Western Australian Disability Support Awards, announced at Crown Perth on the weekend.
Last night, almost 60 supporters gathered at Adelaide Town Hall for the inaugural The Kids Research Institute Australia Adelaide Lecture, Not Just a Sore Throat: The Race to Stop One of the Deadliest Bugs on the Planet.