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Bioenergetic modulation overcomes glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia

Drug-resistant forms of acute lymphoblastic leukaemia (ALL) are a leading cause of death from disease in children.

Vitamin D supplementation, moderate sun exposure, and control of immune diseases

There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes.

CONNECT – Collaborative Network for Neuro-oncology Clinical Trials

Raelene Endersby BSc (Hons) PhD Brainchild Fellow; Co-Head, Brain Tumour Research team raelene.endersby@thekids.org.au Co-Head, Brain Tumour Research

UVR exposure, Vitamin D and type 1 diabetes

Liz Prue Davis Hart MBBS FRACP PhD BSc (Hons) MSc PhD Co-director of Children’s Diabetes Centre Honorary Research Fellow prue.hart@thekids.org.au

Reducing radiotherapy: new antibody gives hope for less toxic cancer treatment

WA Kids Cancer Centre is leading the charge to find innovative new treatments that will allow doctors to ‘dial down’ the amount of toxic treatments needed to fight cancer.

Variants near CCNL1/LEKR1 and in ADCY5 and Fetal Growth Characteristics in Different Trimesters

A recent genome-wide association study identified variants near CCNL1/LEKR1 (rs900400) and in ADCY5 (rs9883204) to be associated with birth weight.

RHD in Australia

Rheumatic heart disease (RHD) is a preventable,devastating condition that disproportionately affects Aboriginal and Torres Strait Islander Australians.

Important clinic update

There is lots of news to report from the clinic including holiday shutdown dates, appointment scheduling, staff updates, and more.

Parental origin of mutations

We hypothesised that MECP2 mutations occur predominantly on the male derived X chromosome.

The Mast Cell Study

Comparing how mast cells are “programmed” in allergic and non-allergic children at one year of age.