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Showing results for "Neuromuscular disorders "
Research
Variants associated with HHIP expression have sexdifferential effects on lung functionLung function is highly heritable and differs between the sexes throughout life. However, little is known about sexdifferential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females.
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ERS technical standard on bronchial challenge testing: General considerations and performance of methacholine challenge testsThis international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test.
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Age- and height-based prediction bias in spirometry reference equationsPrediction bias in spirometry reference equations can arise from combining equations for different age groups,...
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Air travel and the risks of hypoxia in childrenIn infants and children with chronic respiratory disease, hypoxia is a potential risk of aircraft travel.
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The all-age spirometry reference ranges reflect contemporary Australasian spirometryAdvances in statistical modelling have allowed the creation of smoothly changing spirometry reference ranges that apply across a wide age range and better...
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Influence of secular trends and sample size on reference equations for lung function testsThe aim of our study was to determine the contribution of secular trends and sample size to lung function reference equations, and establish the number...
While individual diseases are rare, as a group, rare diseases are common. Recent estimates suggest that between 3% and 6% of the world’s population are affected by rare disease.
The Children's Lung Health Team investigates lung growth and development through infancy, childhood, adolescence and early adulthood, in health and in chronic lung disease, and the impact of preterm birth on lung health outcomes.
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DEFEND CF: Biomarkers to define the treatment end-point for pulmonary exacerbations in cystic fibrosisSensitive and reliable tests are required to monitor lung disease severity in cystic fibrosis.
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Determinants of lung function development from birth to age 5 years: an interrupted time series analysis of a South African birth cohortEarly life is a key period that determines long-term health. Lung development in childhood predicts lung function attained in adulthood and morbidity and mortality across the life course. We aimed to assess the effect of early-life lower respiratory tract infection (LRTI) and associated risk factors on lung development from birth to school age in a South African birth cohort.