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Research
Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade gliomaBevacizumab is well tolerated and appears most effective for rapid tumor control to preserve vision and improve morbidity
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Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic DiseaseIn this concept paper, we discuss multiomic approaches to studying immune dysregulation and highlight some of the challenges and opportunities
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Epidemiology of intussusception before and after rotavirus vaccine introduction in FijiThe incidence of intussusception pre-rotavirus vaccine in Fiji is low
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Dr Charlie McLeodDr Charlie McLeod is a Deputy Head at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at The Kids Research Institute Australia, and of a member of the Centre's Infectious Diseases Implementation Research (IDIR) team.
Research
A modular approach to forecasting COVID-19 hospital bed occupancyMonitoring the number of COVID-19 patients in hospital beds was a critical component of Australia's real-time surveillance strategy for the disease. From 2021 to 2023, we produced short-term forecasts of bed occupancy to support public health decision-making.
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Key elements of Goal-Directed Training for children with cerebral palsy: A qualitative content analysisGoal-directed training is an evidence-based occupational therapy intervention for children with cerebral palsy targeting motor performance and goal attainment. There is variability and limited description on goal-directed training delivery within the studies who found it a successful intervention. The aim of this study was to establish the who, what, why and how of goal directed training according to practicing occupational therapists.
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Parents’ attitudes towards the No Jab No Play legislation in Western Australia: a mixed methods studyMandates provide a relatively cost-effective strategy to increase vaccinate rates. Since 2014, five Australian states have implemented No Jab No Play (NJPlay) policies that require children to be fully immunised to attend early childhood education and childcare services. In Western Australia, where this study was conducted, NJNPlay legislation was enacted in 2019.
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Focused transcription from the human CR2/CD21 core promoter is regulated by synergistic activity of TATA and Initiator elements in mature B cellsMature B cells, CR2/CD21 transcription proceeds from a focused TSS regulated by a non-consensus TATA box, an initiator element and downstream promoter element
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Language, cognitive flexibility, and explicit false belief understanding: Longitudinal analysis in typical development and Specific Language ImpairmentThe hypothesis that language plays a role in theory-of-mind (ToM) development is supported by a number of lines of evidence.