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Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL).

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

IL7 and glucocorticoids coordinately drive aberrant activation of PIM1 and suggests that T-ALL and T-LBL patients could benefit from PIM inhibition

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2017: the Influenza Complications Alert Network (FluCAN)

This report summarises the epidemiology of hospitalisations with laboratory-confirmed influenza during the 2017 influenza season

The safety of seasonal influenza vaccines in Australian children in 2013

Our objective was to examine influenza vaccine safety in Australian children aged under 10 years in 2013.

Leading researchers to explore online abuse in regions

Researchers at The Kids Research Institute Australia are working with boys and young men in regional areas to help stamp out technology-based abuse of girls and young women.

Kids researchers using real tonsils in quest to develop new Strep A vaccine

A new study underway at the Wesfarmers Centre of Vaccines and Infectious Diseases, based at The Kids Research Institute Australia, is deliberately infecting tonsils with Strep A in the laboratory to test a range of potential vaccine candidates.

Setting the agenda: Urgent priorities to close the childhood cancer gap for Aboriginal and Torres Strait Islander children

A review led by the First Nations Childhood Cancer team at The Kids Research Institute Australia has highlighted the urgent need for Indigenous-specific studies focused on cancer outcomes, survivorship and equity.

New study uncovers dual benefit of bone-protecting treatment for childhood leukaemia

A groundbreaking study from cancer researchers at The Kids Research Institute Australia has identified a promising new therapeutic strategy for children battling the most common childhood cancer – B-cell acute lymphoblastic leukaemia.

WA duo recognised as world’s most frequent autism research collaborators of the decade

Director of CliniKids, Professor Andrew Whitehouse, and Professor Murray Maybery, have been identified as the world’s most frequent autism research collaborators of the decade.

Whooping cough vaccine could help in the fight against food allergies

A dose of the whooping cough vaccine might reduce cases of childhood food allergies according to latest research by the Wesfarmers Centre of Vaccines and Infectious Diseases based at The Kids Research Institute Australia.