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Recurrences frequently occur following surgical removal of primary tumors. In many cancers, adjuvant therapies have limited efficacy. Surgery provides access to the tumor microenvironment, creating an opportunity for local therapy, in particular immunotherapy, which can induce local and systemic anti-cancer effects.
High-grade glioma (HGG) cells reactivate neurodevelopmental programs regulated by ion channels to drive tumor progression. The activity of voltage-gated sodium channels (VGSCs) is fundamental to development, a target of blood-brain barrier (BBB)-permeable FDA-approved drugs, and aids tumor advancement in several cancers. However, the contribution of VGSC activity to HGG pathology remains unknown.
Each year in Australia, around 120 children are diagnosed with brain cancer, the leading cause of cancer-related death in young people.
Poverty invades every aspect of a child’s life and, as a growing body of research tells us, affects physical and mental wellbeing as well as future opportunitie
Discover the stories of children whose lives have been impacted by Telethon Kids Institute research.
Within the Institute, we have a commitment to the highest standards of research with pro-active staff ensuring the lab environment is safe and secure.
Understand the relationship between The Kids Research Institute Australia and Wangle Family Insites, a research-driven app to analyse children’s online activity in real time.
Personalised medicine for childhood cancers in West Australia is a step closer thanks to the Zero Childhood Cancer program’s state clinical trial launched today
The WA Kids Cancer Centre has secured $1.1 million in funding from the Medical Research Future Fund’s (MRFF) Paediatric Brain Cancer Research Stream 2 to develop more effective and less toxic treatments for rare brain cancers in infants.
Adam Costantini (SA)