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Linking the westernised oropharyngeal microbiome to the immune response in Chinese immigrantsHuman microbiota plays a fundamental role in modulating the immune response. Western environment and lifestyle are envisaged to alter the human microbiota with a new microbiome profile established in Chinese immigrants, which fails to prime the immune system. Here, we investigated how differences in composition of oropharyngeal microbiome may contribute to patterns of interaction between the microbiome and immune system in Chinese immigrants living in Australia.
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Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial diseaseWe report for the first time that a common stress condition, such as viral infection, can exacerbate mitochondrial dysfunction in a genetic model of mitochondrial disease
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Pcv7-and pcv10-vaccinated otitis-prone children in new zealand have similar pneumococcal and haemophilus influenzae densities in their nasopharynx and middle earPCV10 did not reduce NTHi density in the nasopharynx or middle ear, and was associated with increased pneumococcal nasopharyngeal density
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A systematic review of prevention interventions to reduce prenatal alcohol exposure and fetal alcohol spectrum disorder in indigenous communitiesThere is little evidence that previous interventions aiming to reduce the risk of prenatal alcohol exposure or FASD in Indigenous populations have been effective
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Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificityOur result highlighted that miRNA-target gene network contributes to human disease genetics in a cell type-specific manner
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Severe and Complicated Varicella and Associated Genotypes 10 Years After Introduction of a One-Dose Varicella Vaccine ProgramSevere hospitalized varicella still occurs with a 1-dose varicella program, although predominantly in unvaccinated children
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Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skinOur results show that TRM cells have a fundamental role in the surveillance of subclinical melanomas in the skin by maintaining cancer-immune equilibrium
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Developing evidence-based recommendations for optimal interpregnancy intervals in high-income countries: Protocol for an international cohort studyWe aim to assess the impact of interpregnancy intervals on maternal and child health outcomes in high-income countries
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Intellectual disability and psychotic disorders in children: Association with maternal severe mental illness and exposure to obstetric complicationsMaternal severe mental illness and exposure to obstetric complications contribute separately to the risk of intellectual disability
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Age at menarche and childhood body mass index as predictors of cardio-metabolic risk in young adulthood: A prospective cohort studyEarlier age at menarche may be indicative of a higher risk profile for cardiovascular disease in young adulthood