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Research
Outcomes of latent rheumatic heart disease: External validation of a simplified score in patients with and without secondary prophylaxisSecondary antibiotic prophylaxis reduces progression of latent rheumatic heart disease (RHD) but not all children benefit. Improved risk stratification could refine recommendations following positive screening. We aimed to evaluate the performance of a previously developed echocardiographic risk score to predict mid-term outcomes among children with latent RHD.
Research
In safe hands: child health data storage, linkage and consent for useWhile there is potential for societal benefit from linkage and integration of large datasets, there are gaps in our understanding of the implications for children and young people, and limited inclusion of their views within this discourse. We aimed to understand the views and expectations of children, young people and their parents/caregivers in Aotearoa New Zealand regarding child health data storage, linkage and consent for use.
Research
Development of a sustained release implant of benzathine penicillin G for secondary prophylaxis of rheumatic heart diseaseRegular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery challenges in resource-limited settings. There is an urgent need for new approaches for secondary prophylaxis, such as an implant which could provide sustained penicillin concentrations for more than 6 months.
Research
The evidence that rheumatic heart disease control programs in Australia are making an impactRheumatic heart disease (RHD) comprises heart-valve damage caused by acute rheumatic fever (ARF). The Australian Government Rheumatic Fever Strategy funds RHD Control Programs to support detection and management of ARF and RHD. We assessed epidemiological changes during the years of RHD Control Program operation.
Research
Determination of Tr1 cell populations correlating with distinct activation states in acute IAV infectionType I regulatory (Tr1) cells are defined as FOXP3-IL-10-secreting clusters of differentiation (CD4+) T cells that contribute to immune suppression and typically express the markers LAG-3 and CD49b and other co-inhibitory receptors. These cells have not been studied in detail in the context of the resolution of acute infection in the lung.
A powerful data tool developed by international child development researcher Professor Sally Brinkman and former research assistant Tom Brown could improve early childhood support for children around the world after being launched in Dubai this year.
A program unfolding in four very diverse locations across Western Australia is working to give children aged 0–4 the best start in life.
Not too long ago, if you had mentioned physical activity to educators at the Sonas Early Learning & Care centres run by Shelley Prendergast, they would automatically have reached for the trusty old obstacle course.
Aboriginal families and communities have endured the imposition of countless ‘solutions’ and had to live with the consequences of these ineffective initiatives. Those consequence are sadly evident in the unrelenting gap in outcomes for Aboriginal kids, compared with other Australian children.
WA Kids Cancer Centre is leading the charge to find innovative new treatments that will allow doctors to ‘dial down’ the amount of toxic treatments needed to fight cancer.