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Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins.
Surfactant, which was first identified in the 1920s, is pivotal to lower the surface tension in alveoli of the lungs and helps to lower the work of breathing and prevents atelectasis. Surfactant proteins, such as surfactant protein B and surfactant protein C, contribute to function and stability of surfactant film.
This paper presents the first causal estimates of the effect of weather on children's time allocation. It exploits exogenous variations in local weather observed during the random diary dates of two nationally representative cohorts of Australian children whose time-use diaries were surveyed biennially over 10 years.
Surgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is common, with a relapse rate of around 45% for non-small cell lung cancer. The tumour draining lymph nodes (dLN) are resected at the time of surgery for staging purposes, and this cannot be a null event for patient survival and future response to immune checkpoint blockade treatment. This project investigates cancer surgery, lymphadenectomy, onset of metastatic disease, and response to immunotherapy in a novel model that closely reflects the clinical setting. In a murine metastatic lung cancer model, primary subcutaneous tumours were resected with associated dLNs remaining intact, completely resected or partially resected.
In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss 'beneficial' exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome.
The current diagnostic pathways for cognitive impairment rarely identify babies at risk before 2 years of age. Very early detection and timely targeted intervention has potential to improve outcomes for these children and support them to reach their full life potential. Early Moves aims to identify early biomarkers, including general movements (GMs), for babies at risk of cognitive impairment, allowing early intervention within critical developmental windows to enable these children to have the best possible start to life.
Read our Q+A with Aurora intern Mikayla Helms.
Regular physical activity provides children with health and developmental benefits. This study investigated if active play and walking with the family dog was associated with better social-emotional development in young children.
Diabetes distress, self-efficacy and health literacy are associated with diabetes self-management and health outcomes. Measures of coping styles and their impact on diabetes self-management and diabetes-related distress may add value in identifying those at risk of poorer health outcomes. Current evidence of associations between psychological flexibility/inflexibility and diabetes related health outcomes is limited.
Citation: Ibilola O, Silva D. Environmental (Perinatal) risk factors of ADHD in a sibling control design study. Open Access Journal of Behavioural
The Neurological Hand Deformity Classification (NHDC) is an impairment-based tool that classifies hand deformity into one of two ordinal scales: flexion or extension deformities. Classification is made from live observation or from recorded video footage. Differentiation between the levels is determined by wrist position and wrist and finger movement.
Aboriginal researchers from The Kids Research Institute Australia have been recognised for their contributions to their communities at multiple awards ceremonies over the weekend.
Senior Embrace researcher Dr Alix Woolard has called for more support for NICU parents and families at the 2025 Perinatal and Infant Mental Health Symposium.
Walkern Katatdjin researcher and lead author Mx Shakara Liddelow-Hunt leads a conversation with the community on the key actions to include in the Roadmap.
Thomas Betts is a semi-finalist in the National Indigenous Times Indigenous Community Leadership Award.
Embrace researchers have begun development of a parenting program that is specific to the needs of Aboriginal and Torres Strait Islander people.
Associate Professor Yael Perry and project coordinator Holly Moss reflect on their experiences attending the busy annual event.
We asked our podcast guest Hayley to recount her experiences navigating the healthcare system for Fibroid Awareness Month.
Embracing the Mind's third season will focus on women's wellbeing, exploring reproductive health, neurodiversity, and the changing face of healthcare in Australia.
Sport and fantasy sport gambling can lead to a higher risk of problem gambling behaviour in young men, new research has found.