Associations between EEG measures and clinical severity in CDKL5 deficiency disorder

Citation:
Saby JN, Fleysh D, Kessler C, Jacoby P, Saldaris JM, Suter B, ……. Downs J, Leonard H, Demarest S, Benke TA, Marsh ED. Associations between EEG measures and clinical severity in CDKL5 deficiency disorder. Clin Neurophysiol. 2026;191.

Keywords:
Biomarkers; CDKL5 deficiency disorder; Developmental and epileptic encephalopathy; EEG; Evoked potentials

Abstract:
Prior work has shown that quantitative EEG and evoked potentials (EPs) may be useful as objective measures of brain function for CDKL5 deficiency disorder (CDD), a developmental and epileptic encephalopathy associated with pathogenic variants in CDKL5. The current study builds on this work by examining associations between EEG/EP parameters and CDD-specific symptom severity in a large, representative cohort of individuals with CDD.