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In this paper we provide an integrative synthesis of eight systematic reviews that compromise our systematic review series entitled ‘Population Perspectives on Nurturing Relational Health from Early Life’. We reflect on what we know, what we don’t know, and what we need to know to better safeguard the interpersonal world of the child.
Each year, 11% (15 million) of the world’s babies are delivered before 37 weeks’ gestation.
The Early Years Partnership is a 10-year (2018-2028) partnership between the WA State Government (Departments of Communities, Health, and Education), Minderoo Foundation and The Kids Research Institute Australia as the evidence and evaluation partner.
Hallmarks of cystic fibrosis (CF) airway disease include bronchiectasis, airway inflammation by infiltrating polymorphonuclear neutrophils (PMNs) and recurring infection.
Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV1) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV1 decline in adolescence and adulthood have not slowed. This suggests that interventions aimed at preventing lung disease should be targeted to mild disease and commence in early life.
Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage
Cross-sectional studies implicate neutrophilic inflammation and pulmonary infection as risk factors for early structural lung disease in infants and young...
Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic
CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis CrossTalk opposing view: mucosal
The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis Lung inflammation and infection are common