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Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease

Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease. What did you find? We focused on lipid molecules which we know

Chronic Lung Disease of Prematurity

Each year, 11% (15 million) of the world’s babies are delivered before 37 weeks’ gestation.

Time to get serious about the detection and monitoring of early lung disease in cystic fibrosis

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV1) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV1 decline in adolescence and adulthood have not slowed. This suggests that interventions aimed at preventing lung disease should be targeted to mild disease and commence in early life.

Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage

Progression of early structural lung disease in young children with cystic fibrosis assessed using CT

Cross-sectional studies implicate neutrophilic inflammation and pulmonary infection as risk factors for early structural lung disease in infants and young...

Epithelial Drivers of Neutrophil Plasticity in Early Cystic Fibrosis Lung Disease

Hallmarks of cystic fibrosis (CF) airway disease include bronchiectasis, airway inflammation by infiltrating polymorphonuclear neutrophils (PMNs) and recurring infection.

Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease

Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic Fibrosis Lung Disease Of Pigs, Mice, and Men: Understanding Early Triggers of Cystic

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis

CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis CrossTalk opposing view: mucosal

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis

The cumulative effect of inflammation and infection on structural lung disease in early cystic fibrosis Lung inflammation and infection are common

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story?

Air trapping in early cystic fibrosis lung disease—Does CT tell the full story? Abstract Introduction: Mosaic attenuation on expiratory chest