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The dramatic rise in early childhood allergic diseases indicates the specific vulnerability of the immune system to early life environmental changes.
Early infancy is a critical period for immune development. In addition to being the primary food source during early infancy, human milk also provides multiple bioactive components that shape the infant gut microbiome and immune system and provides a constant source of exposure to maternal microbiota. Given the potential interplay between allergic diseases and the human microbiome, this study aimed to characterise the milk microbiome of allergic mothers.
IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.
The increase in childhood allergic disease in recent decades has coincided with increased folic acid intakes during pregnancy. Circulating unmetabolized folic acid (UMFA) has been proposed as a biomarker of excessive folic acid intake. We aimed to determine if late-pregnancy serum UMFA and total folate concentrations were associated with allergic disease risk in the offspring at 1 y of age in a population at high risk of allergy.
The underlying pathogenesis of pediatric obstructive sleep disordered breathing (SDB) and recurrent tonsillitis (RT) are poorly understood but need to be elucidated to develop less invasive treatment and prevention strategies.
Our findings are crucial in demonstrating that the Northern Territory STS clone is not STX resistant
With the help of clinicians and families who have children with Rett syndrome, our research aims to improve understanding of Rett syndrome.
This review made the important observation that registries with biobanks had the function of both stand-alone registries and stand-alone rare disease biobanks
Melissa Andrew Gail Jenny Videos Licari Whitehouse Watch and listen to Andrew Alvares Downs PhD PhD PhD BApplSci (physio) MSc PhD Senior Research
On Monday 1 September, childhood cancer researcher Jacob Byrne is lacing up his running shoes and taking the first steps of an extraordinary challenge: 30 marathons in 30 days across Perth.