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To assess the effects of topical antiseptics for people with chronic suppurative otitis media

To assess the effects of systemic antibiotics for people with chronic suppurative otitis media.

To assess the effects of topical antibiotics for people with chronic suppurative otitis media.

To assess the effects of adding a topical steroid to topical antibiotics in the treatment of people with chronic suppurative otitis media

Head, Ear and Hearing Health

Indigenous Australian children suffer the highest rates of impetigo (skin sores) in the world, which can result in serious immune complications including chronic kidney and possibly rheumatic heart disease.

Rheumatic heart disease (RHD) is the most common form of acquired heart disease worldwide. In RHD, volume loading from mitral regurgitation leads to left ventricular (LV) dilatation, increased wall stress, and ultimately LV dysfunction. Improved understanding of LV dynamics may contribute to refined timing of intervention.

Acute rheumatic fever (ARF) is a multiorgan inflammatory disorder that results from the body's autoimmune response to pharyngitis or a skin infection caused by Streptococcus pyogenes (Strep A). Acute rheumatic fever mainly affects those in low- and middle-income nations, as well as in indigenous populations in wealthy nations, where initial Strep A infections may go undetected.

Vaccine development and implementation decisions need to be guided by accurate and robust burden of disease data. We developed an innovative systematic framework outlining the properties of such data that are needed to advance vaccine development and evaluation, and prioritize research and surveillance activities.

First Findings Published in Origins Sub-Project