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We aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort.

To assess the determinants of early lung function in African infants.

This study will conduct a detailed lung health assessment in a follow-up of a group of preterm individuals at 19 years of age.

Understanding if ongoing inflammation in the lungs contributes to the poor lung health experienced by some children who were born preterm.

Inflammation and oxidative stress play a key role in the development of bronchopulmonary dysplasia (BPD), possibly contributing to persistent respiratory morbidity after preterm birth. We aimed to assess if inflammatory markers were elevated in exhaled breath condensate (EBC) of infants born very prematurely (< 32 weeks gestation) at 12-16 corrected months of age, and if increased levels were associated with BPD diagnosis and respiratory morbidity.

Environmental exposure to phthalates and bisphenol A (BPA), chemicals used in the production of plastics, may increase risk for asthma and allergies. However, little is known about the long-term effects of early life exposure to these compounds.

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.

Graham Shannon Hall Simpson BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (hons), PhD Honorary Research Associate Head, Strong Beginnings Research,

This study aims to show that asthma and allergies in individuals can be predicted before it occurs based on individual family history and information on the early environment.

In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated with abnormal ventilation distribution.