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The causal impact of mental health on tobacco and alcohol consumption: An instrumental variables approach

The reciprocal relationship between psychiatric and substance use disorders is well-known, yet it remains largely unknown whether mental health morbidity causally leads to addictive behaviours. This paper utilises a fixed effects instrumental variables model, which is identified by time-varying sources of plausibly exogenous variations in mental health, and a nationally representative panel dataset from Australia to present robust evidence on the causal impact of mental distress on cigarette smoking and alcohol drinking behaviours.

Adjusting for under-identification of Aboriginal and/or Torres Strait Islander births in time series produced from birth records

Statistical time series derived from administrative data sets form key indicators in measuring progress.

A data infrastructure for improving Aboriginal life pathways: the influence of health, education, child protection and justice systems over time and across generations

Incarceration represents a source of ongoing socioeconomic and health inequity between Aboriginal and non-Aboriginal populations, limiting life changes and opportunities.

A phase 3, multicenter, randomized, double-blind study to evaluate the interchangeability of V114, a 15-valent pneumococcal conjugate vaccine, and PCV13 with respect to safety, tolerability, and immunogenicity in healthy infants (PNEU-DIRECTION)

Pneumococcal disease (PD) remains a major health concern globally. In children, pneumococcal conjugate vaccines (PCVs) provide protection against PD from most vaccine serotypes, but non-vaccine serotypes contribute to residual disease. V114 is a 15-valent PCV containing all 13 serotypes in Prevnar 13™ and public health important serotypes 22F and 33F. This phase 3 study evaluated safety and immunogenicity of mixed PCV13/V114 regimens using a 3 + 1 dosing schedule when changing from PCV13 to V114 at doses 2, 3, or 4. 

Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

The Human Phenotype Ontology is a standardized vocabulary of phenotypic abnormalities used by researchers, clinicians, informaticians and electronic health record systems

Michael Slee

Research Associate PLAYCE

Teens with diabetes cope with the additional burden of CV protection

ACE inhibitors and statins are well tolerated in teenagers with Type 1 Diabetes but more evidence is required to demonstrate whether they are effective

Diabetes link to deadly diseases

New research led by The Kids' PhD student Matthew Cooper has found that some children with T1D have an increased risk of developing vascular diseases.

Varicella vaccine effectiveness over 10 years in Australia; moderate protection from 1-dose program

Although Australia's program has impacted on the burden of varicella disease, single dose Vaccine Effectiveness against varicella hospitalisation is only moderate

Trans Tasman action to fast track rheumatic fever vaccine

Prime Ministers of Australia and New Zealand have agreed to provide $3M to help fast-track the development of a vaccine against rheumatic fever.