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As well as ORIGINS long-term core research, there are a number of clinical trials, early interventions and shorter-term research studies that sit within ORIGINS. Known as sub-projects, these studies look at multiple aspects of child and family health and development.
Chinese immigrants living in Australia experience increased allergic conditions: asthma, eczema, hay fever and wheeze. Recently we reported diminished innate cytokine responses in long-term immigrants, potentially increasing their pathogenic viral load and microbial carriage. We hypothesise that a Western environment changes the nasal microbiome profile, and this altered profile may be associated with the development of allergic conditions. In this cross-sectional study, we aimed to examine the loading of viral and microbial respiratory pathogens in the upper airway.
Honorary Research Associate
Eczema often precedes the development of asthma in a disease course called the 'atopic march'.
Non-invasive techniques for measuring lung mechanics in infants are needed for a better understanding of lung growth and function...
The burden of bronchiectasis is disproportionately high in Aboriginal adults, with early mortality. Bronchiectasis precursors, that is, protracted bacterial bronchitis and chronic suppurative lung disease, often commence in early childhood.
A recent systematic review of 5 randomized clinical trials, found that early egg introduction was associated with reduced egg allergy.
A clinically significant history of fracture in combination with low bone densitometry findings is necessary for a diagnosis of osteoporosis in Rett Syndrome
Researchers at The Kids are harnessing the power of apps and other online tools to ensure the results of their research reach those who need it most – children, young people and families.
We employed a systems biology approach to delineate upper airway gene network patterns underlying asthma exacerbation phenotypes in children.