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Characterisation of lung function trajectories and associated early-life predictors in an Australian birth cohort study

There is growing evidence that lung function in early-life predicts later lung function. Adverse events over the lifespan might influence an individual’s lung function trajectory, resulting in poor respiratory health. The aim of this study is to identify early-life risk factors and their impact on lung function trajectories to prevent long-term lung impairments.

The ventilatory response to hypoxia is blunted in some preterm infants during the second year of life

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life.

Predicting long term lung health outcomes in young adults born very preterm (WALHIP 19 year old follow-up)

This study will conduct a detailed lung health assessment in a follow-up of a group of preterm individuals at 19 years of age.

Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth

Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM.

Are preterm birth and intra-uterine growth restriction more common in Western Australian children of immigrant backgrounds? A population based data linkage study

Our findings illustrate the vulnerabilities of children born to foreign women from low and middle-income countries

The development and refinement of a sensitive bedside test to continually measure the severity of BPD and lung development in preterm infants

Graham Jane Shannon Hall Pillow Simpson BAppSci PhD CRFS FANZSRS FThorSoc FERS BMedSci (Dist) MBBS, PhD (Dist) FRACP BMedSci (hons), PhD Honorary

Applying spirometry phenotypes to a longitudinal cohort born very preterm

To better characterise prematurity-associated lung disease, adult spirometry phenotype classifications (obstructive lung disease, preserved ratio impaired spirometry and dysanapsis) have been applied to children born preterm. It is unknown how these phenotypes track over time.

Understanding the relative contributions of the lung, respiratory muscles and the blood vessels to severity of chronic lung disease in very preterm infants (PIFCO Follow-up)

Graham Ingrid Shannon Hall Laing Simpson BAppSci PhD CRFS FANZSRS FThorSoc FERS BSc PhD BMedSci (hons), PhD Honorary Research Associate Head,

Fine particulate matter and risk of preterm birth and pre-labor rupture of membranes in Perth, Western Australia 1997-2007: A longitudinal study

A recent longitudinal study reported an association between fine particulate (PM2.5) exposure and preterm birth (PTB) in a US cohort.

Early mortality among aboriginal and non-Aboriginal women who had a preterm birth in Western Australia: A population-based cohort study

Having a preterm (<37 weeks' gestation) birth may increase a woman's risk of early mortality. Aboriginal and Torres Strait Islander women have higher preterm birth and mortality rates compared with other Australian women.