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Research

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

Identified CCI-007 as a novel small molecule that displays rapid toxicity towards a subset of MLL-r, CALM-AF10 and SET-NUP214 leukemia cell lines

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Theory-Based Design and Development of a Socially Connected, Gamified Mobile App for Men About Breastfeeding (Milk Man)

The development of Milk Man followed a best practice approach, including the involvement of a multidisciplinary team and grounding in behavior change theory

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Baseline grey matter volume of non-transitioned "ultra high risk" for psychosis individuals with and without attenuated psychotic symptoms at long-term follow-up

This study found that differences in regional grey matter volume are discernible at an early stage of ultra-high risk psychosis

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Trends in smoking rates by level of psychological distress-time series analysis of US national health interview survey data 1997-2014

People with mental health problems have high rates of smoking, and represent a large proportion of adult smokers in the United States.

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Bile signalling promotes chronic respiratory infections and antibiotic tolerance

Bile acid signalling is a leading trigger for the development of chronic phenotypes underlying the pathophysiology of chronic respiratory disease

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Persistent and compartmentalised disruption of dendritic cell subpopulations in the lung following influenza A virus infection

Immunological homeostasis in the respiratory tract is thought to require balanced interactions between networks of dendritic cell (DC) subsets in lung...

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Dog walking is associated with more outdoor play and independent mobility for children

It is plausible that dog-facilitated activity rather than dog ownership per se encourages children's physical activity behaviors.

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Common variation near ROBO2 is associated with expressive vocabulary in infancy

In this paper we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers of European descent from up to four studies of the...

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Confirmation of childhood acute lymphoblastic leukemia Variants, ARID5B and IKZF1, and interaction with parental environmental exposures

The polygenic nature of childhood ALL predisposition together with the timing of environmental triggers may hold vital clues for disease etiology.

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Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood

The impact of breast milk feeding on susceptibility to asthma in childhood is highly controversial, due in part to failure of the majority of studies in the...