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Research

Voices behind the statistics: A systematic literature review of the lived experience of rheumatic heart disease

This systematic review presents a critical, interpretive analysis of publications that include lived experiences of rheumatic heart disease

Research

How many words are Australian children hearing in the first year of life?

These results show that a word gap related to maternal education is not apparent up to twelve months of age

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Factors Associated With 90-Day Readmission After Stroke or Transient Ischemic Attack: Linked Data From the Australian Stroke Clinical Registry

Apart from comorbidities and patient-level characteristics, readmissions after stroke/transient ischemic attack were associated with discharge destination

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Effects of UVR exposure on the gut microbiota of mice and humans

Both human and murine studies report that multiple exposures to sub-erythemal UV radiation can increase the diversity of the gut microbiome

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The relationship between abdominal pain and emotional wellbeing in children and adolescents in the Raine Study

Abdominal pain in children and adolescents associates with depression, anxiety, being bullied, unhappiness and reduced overall health-rating during adolescence

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Clinical characteristics of Western Australian children diagnosed with type 2 diabetes before 10 years of age

We aimed to describe the characteristics of Western Australian children aged less than 10 years diagnosed with type 2 diabetes between June 2000 and June 2017

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Sharing is Caring: A Study of Food-Sharing Practices in Australian Early Childhood Education and Care Services

This paper supports the practice of food sharing in Early Childhood Education and Care settings and calls for them to become embedded in everyday operations

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The impact of weather on time allocation to physical activity and sleep of child-parent dyads - Life Course Centre Working Paper Series 2021

This study explores the differential impact of weather on time allocation to physical activity and sleep by children and their parents. We use nationally representative data with time use indicators objectively measured on multiple occasions for more than 1,100 child-parent pairs, coupled with daily meteorological data.

Research

Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma

Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy.

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A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study

Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab.