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ORIGIN-1 trial: study protocol for an organoid-guided N-of-1 trial evaluating CFTR modulator response in cystic fibrosis with rare non-F508del mutations

Cystic fibrosis (CF) is a genetic condition caused by mutation of the cystic fibrosis transmembrane regulator (CFTR) gene. Recently licensed modulato…

International Society of Pediatric Respiratory Diseases (INSPiRED) call to action: A Global Ban on Electronic Cigarette Sales to Protect our Children's Future

Electronic cigarettes (e-cigarettes) have become a leading form of nicotine use among children and adolescents worldwide. The World Health Organizati…

Advancing equity: six-year respiratory outcomes in young Indigenous children following early respiratory disease detection

Protracted bacterial bronchitis (PBB), chronic suppurative lung disease (CSLD) and bronchiectasis are parts of a disease spectrum characterised by ch…

First global synthesis of heat-related mental health impacts in children and young people: a systematic review and meta-analysis

Climate change is increasing the frequency and severity of non-optimal temperatures and heatwaves, posing risks to public health, especially for chil…

Long term lung health in children: new emerging threats and preventive strategies

The long-term consequences of early adverse exposures are well known but is becoming clear that early means not just in pregnancy but also in at leas…

Stability and age-specific patterns of rhinovirus circulation in children observed over 3 decades

Rhinoviruses (RV) are the most common respiratory viruses globally and a major cause of airway symptoms in children and individuals with asthma. Alth…

Personal network inference identifies children at risk of recurrent wheezing and asthma

Wheezing and asthma exacerbations are leading causes of pediatric hospital admissions. Predicting which children will experience persistent exacerbat…

Systematic review of climate change interventions for improving child health

Children are disproportionately affected by the negative health effects of climate change. We did a systematic review to synthesise the available evi…

Understanding Otitis Media Among Aboriginal Children in the Kimberley Region of Western Australia: An Opportunity to Improve Health Outcomes

To assess the prevalence, clinical features and treatment of otitis media (OM) among Aboriginal children in the Kimberley region of Western Australia…