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Research

Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study.

Research

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models.

Research

What Influences Decision-Making for Cochlear Implantation in Adults? Exploring Barriers and Drivers From a Multistakeholder Perspective

To explore the factors influencing the uptake of cochlear implants in adults, determine the impact of each factor, and to conceptualize the journey to implantation from a multistakeholder perspective. Concept mapping was used to integrate input from multiple stakeholders, each with their own experience and expertise.

Research

Validation of the Dutch version of the Multidimensional Adolescent Functioning Scale (MAFS)

The Multidimensional Adolescent Functioning Scale (MAFS) is a 23-item, self-report questionnaire assessing psychosocial functioning in adolescents aged 12-17 years. It captures three domains of functioning: 'general functioning', 'family-related functioning', and 'peer-related functioning'. The original English version has good psychometric properties. The aim of the current paper was to translate the MAFS to Dutch and to investigate the psychometric properties of this translation.

Research

Impact of a multimodal exercise program on tibial bone health in adolescents with Development Coordination Disorder: an examination of feasibility and potential efficacy

Developmental coordination disorder (DCD) compromises bone health purportedly due to lower levels of physical activity. The potential of an exercise intervention to improve bone health parameters in adolescents with DCD has not previously been studied. This study thus aimed to determine the impact of a multimodal exercise intervention on bone health in this population at-risk of secondary osteoporosis.

Research

The Importance of School Pedagogical and Social Climate to Students’ Unauthorized Absenteeism – a Multilevel Study of 101 Swedish Schools

While individual and family factors behind students’ school absenteeism are well-researched, fewer studies have addressed school climate factors. This study investigated the association between school climate in Swedish schools and students’ absenteeism.

News & Events

Autism study helping kids reach their full potential

Professor Andrew Whitehouse and the Autism team at The Kids are working with Joondalup Health Campus as part of ORIGINS to gain greater insight into how the brain develops in children who have difficulties with language.

News & Events

Back to nature

ORIGINS is investigating the influence of nature, from pregnancy through the early years of childhood and its impact on later health, as part of the nature relatedness study.

News & Events

Language development: Milestones are a guide

While learning language is a lifelong journey, the first few years of life are especially important. So how do you know if your child’s language is on track?

Available Data and Biological Samples

ORIGINS is collecting data from multiple sources from the mother, infant and partner at multiple timepoints from gestation through to five years of age.

Useful Documents for Collaborators

A list of documents, forms and resources for current or potential collaborators to download

Pediatric Burns

This project aims to investigate the impact of a non-severe burn injury on children's health for life.

Urinary Ferritin as a Non-Invasive Means of Assessing Iron Status in Young Children

Exploring whether urinary ferritin can be used as an alternative biomarker for measuring iron status in young children over blood draws.

CEED: Colostrum Exclusivity in Early Development

Research shows at least a third of newborns receive formula in hospital, a practice shown to be associated with an increased risk of cow’s milk allergy.

The Mediterranean Diet

This study aims to examine how a Mediterranean diet and exercise in pregnancy impacts on neonatal body fat composition at birth and weight at one year of age.

CEED: Colostrum Exclusivity in Early Development

Research shows at least a third of newborns receive formula in hospital, a practice shown to be associated with an increased risk of cow’s milk allergy.