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Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemiaWe identified consistent hypomethylation of the CTGF locus in primary pre-B ALL specimens regardless of CTGF expression.
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DSM-IV-TR and DSM-5 eating disorders in adolescents: Prevalence, stability, and psychosocial correlates in a population-based sampleEating disorder prevalence rates were significantly greater when using DSM-5 than DSM- IV-TR criteria, at all time points for females and at age 17 only...
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A "bottom-up" approach to aetiological research in autism spectrum disordersAutism spectrum disorders (ASD) are currently diagnosed in the presence of impairments in social interaction and communication, and a restricted range of...
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Common variation contributes to the genetic architecture of social communication traitsSocial communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development.
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Cholesteryl ester transfer protein gene polymorphisms increase the risk of fatty liver in females independent of adiposityEnvironmental factors including excessive caloric intake lead to disordered lipid metabolism and fatty liver disease.
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Chest computed tomography: a validated surrogate endpoint of cystic fibrosis lung disease?Clinical trials for the treatment of cystic fibrosis (CF) lung disease are important to test and optimise new therapeutic interventions.
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Early Onset Binge Eating and Purging Eating Disorders: Course and Outcome in a Population-Based Study of AdolescentsPurging at age 17 and externalising behaviour problems at age 14 were the strongest predictors of eating disorder persistence to age 20.
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Resourceful and creative methods are necessary to research rare disordersOur investigation used the infrastructure of InterRett, established in 2002 with dual aims of encour- aging international collaboration and ascertaining the...
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The International Collaboration for Autism Registry Epidemiology (iCARE): Multinational Registry-Based Investigations of Autism Risk Factors and TrendsiCARE provides a unique, unprecedented resource in autism research that will significantly enhance the ability to detect environmental and genetic...
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Associations between Handedness and Cerebral Lateralisation for Language: A Comparison of Three Measures in ChildrenIt has been suggested that quantitative measures of differential hand skill or reaching preference may provide more valid measures than traditional...