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We won't find what we don't look for: Identifying barriers and enablers of chronic wet cough in Aboriginal children

Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities

Bile signalling promotes chronic respiratory infections and antibiotic tolerance

Bile signalling promotes chronic respiratory infections and antibiotic tolerance Despite aggressive antimicrobial therapy, many respiratory

Professor Jonathan Carapetis honoured at 2021 Western Australian of the Year Awards

Congratulations to The Kids Research Institute Australia Director Professor Jonathan Carapetis AM, who last night won the Professions Award at the 2021 Western Australian of the Year Awards.

An infant nasal microbial gene atlas uncovers intervention-driven microbiome shifts and salt-resistant pathogen expansion

Functional studies of how early-life interventions shape the airway microbiome remain scarce. Here, we performed metagenomic sequencing of 704 longitudinal nasal swabs from infants with and without cystic fibrosis (CF) to construct and characterize a non-redundant gene atlas of the infant nasal microbiome. We aimed to determine how the nasal microbiome is perturbed by early therapies, as CF is commonly treated with inhaled hypertonic saline to improve mucociliary clearance.

Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model

Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model.

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis. Abstract Although destructive airway

Treat early to protect lungs

Early intervention is being touted as the key to preventing lung damage in children with cystic fibrosis.

Mapping changes in immune cell populations in gestational tissues over the course of pregnancy

This is a strategic “pilot” project in which we are seeking basic information on the immune cell content of gestational tissues.

Gestational age at birth and body size from infancy through adolescence: An individual participant data meta-analysis on 253,810 singletons in 16 birth cohort studies

Preterm birth is the leading cause of perinatal morbidity and mortality and is associated with adverse developmental and long-term health outcomes, including several cardiometabolic risk factors and outcomes. However, evidence about the association of preterm birth with later body size derives mainly from studies using birth weight as a proxy of prematurity rather than an actual length of gestation. We investigated the association of gestational age (GA) at birth with body size from infancy through adolescence.

Premmie twins defy the odds

When Samuel and James Considine were born in October 2003, perilously close to what the medical world describes as the limit of viability, each weighed just 700 grams and could fit into the palm of their father’s hand.