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Clinical Predictors of Respiratory Failure in Paediatric Neuromuscular Disorders

This research project is a collaboration between The Kids Research Institute Australia, Muscular Dystrophy Western Australia, Perth Children’s Hospital and Curtin University.

Five innovative research projects supported by Inspiration Awards 2022

Valued at a total of $440,000, the Wal-yan Respiratory Research Centre Inspiration Awards 2022 will support five cutting-edge research projects.  

HDL remodeling and enrichment with apoCIII and apoE in Indigenous Australians

Indigenous Australians have an increased risk of type 2 diabetes mellitus and premature cardiovascular disease. Subpopulations of high-density lipoprotein (HDL) have been associated with increased cardiovascular risk, but HDL composition, size, or function have not been studied in Indigenous Australians.

Randomised controlled trial of perinatal vitamin D supplementation to prevent early-onset acute respiratory infections among Australian First Nations children: the 'D-Kids' study protocol

Globally, acute respiratory infections (ARIs) are a leading cause of childhood morbidity and mortality. While ARI-related mortality is low in Australia, First Nations infants are hospitalised with ARIs up to nine times more often than their non-First Nations counterparts.

A single blinded, phase IV, adaptive randomised control trial to evaluate the safety of coadministration of seasonal influenza and COVID-19 vaccines (The FluVID study)

We evaluated the frequency of moderate and severe adverse events following coadministration of seasonal influenza vaccine (SIV) versus placebo with COVID-19 vaccines among adults to support practice guidelines. 

A phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of catch-up vaccination regimens of V114, a 15-valent pneumococcal conjugate vaccine(PNEU-PLAN)

Despite widespread use of pneumococcal conjugate vaccines (PCVs) in children, morbidity and mortality caused by pneumococcal disease (PD) remain high. In addition, many children do not complete their PCV course on schedule. V114 is a 15-valent PCV that contains two epidemiologically important serotypes, 22F and 33F, in addition to the 13 serotypes present in PCV13, the licensed 13-valent PCV.

OMIP 076: High-dimensional immunophenotyping of murine T-cell, B-cell, and antibody secreting cell subsets

There is now considerable evidence demonstrating that both prenatal and postnatal exposure to particular classes of microbial stimuli can provide beneficial signals during early life immune development, resulting in the protection against future inflammatory disease.

Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

We now have a growing number of epigenetic alterations in disease, and this offers a chance to increase sensitivity and specificity of future diagnostics and therapies

Hesitant compliers': Qualitative analysis of concerned fully-vaccinating parents

Parents interpreted pivotal vaccine-related events in the community as requiring them to take personal responsibility for vaccine decisions

Early life nutrition and the opportunity to influence long-term health: an Australasian perspective

There is significant data to support the hypothesis that early life nutrition in the fetus, infant and young child can have profound effects on long-term health