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Undiagnosed Diseases Network International (UDNI): White paper for global actions to meet patient needs

This white paper discusses the global progress in understanding novel diseases with the aim of encouraging more collaboration between international...

Insights into the possible role of IFNG and IFNGR1 in Kala-azar and Post Kala-azar Dermal Leishmaniasis in Sudanese patients

Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence

Will Global Climate Change Alter Fundamental Human Immune Reactivity: Implications for Child Health?

We postulate several mechanisms whereby climate change sensitive exposures and conditions will subtly impair aspects of the human immune response

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an...

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy

Food allergy is mediated by a combination of genetic and environmental risk factors, potentially mediated by epigenetic mechanisms.

The correlation between reading and mathematics ability at age twelve has a substantial genetic component

Dissecting how genetic and environmental influences impact on learning is helpful for maximizing numeracy and literacy.

Keyhole limpet haemocyanin - A model antigen for human immunotoxicological studies

This report systematically reviews the human clinical studies that have used trans-cutaneous KLH immunization for assessment of the influence of various...

What is the optimal level of vitamin D?: Separating the evidence from the rhetoric

New evidence indicates that both high and low 25(OH)D levels may be associated with increased health risks.

Is the effect of compulsory community treatment

We investigated whether a reduction of preventable deaths from physical disorders was mediated by better access to specialized medical procedures.

Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice

To investigate the immune capabilities of peripheral tissue DCs generated in vivo from the BM of UV-irradiated mice, chimeric mice were established.