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Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL.

Preclinical Evaluation of Carfilzomib for Infant KMT2A-Rearranged Acute Lymphoblastic Leukemia

Infants with KMT2A-rearranged B-cell precursor acute lymphoblastic leukemia (ALL) have poor outcomes. There is an urgent need to identify novel agents to improve survival. Proteasome inhibition has emerged as a promising therapeutic strategy for several hematological malignancies. The aim of this study was to determine the preclinical efficacy of the selective proteasome inhibitor carfilzomib, for infants with KMT2A-rearranged ALL.

Romidepsin enhances the efficacy of cytarabine in vivo, revealing HDAC inhibition as a therapeutic strategy for KMT2A-rearranged acute lymphoblastic leukemia

In this study, we investigate the in vivo synergy between romidepsin and cytarabine

Prevalence of Racial Discrimination in a Cohort of Aboriginal and Torres Strait Islander Children

This study looked at the frequency of racism experiences over time in a population of Aboriginal and Torres Strait Islander children

A randomised controlled trial of an iPad-based application to complement early behavioural intervention in Autism Spectrum Disorder

Technology-based interventions may provide a relatively low-cost addition to existing therapist-delivered interventions for children with ASD

Risk factors for low receptive vocabulary abilities in the preschool and early school years in the longitudinal study of Australian children

Receptive vocabulary development is a component of the human language system that emerges in the first year of life and is characterised by onward expansion...

The Early Years Partnership

The Early Years Partnership is a 10-year (2018-2028) partnership between the WA State Government (Departments of Communities, Health, and Education), Minderoo Foundation and The Kids Research Institute Australia as the evidence and evaluation partner.

Bilingualism, Parental English Skills and Child and Adolescent Development

This project will provide important policy directions for design of language educational programs in Australian schools, developing a multi-cultural society, multi-lingual workforce, sourcing of immigrants from different language backgrounds and English abilities in order to obtain the best developmental outcomes

The effectiveness of a Consumer Centred Tobacco Management (CCTM) approach in enabling mental health consumers to reduce or quit smoking

The aim of this pilot study is to test if the CCTM approach is more effective than business as usual methods at supporting mental health consumers to reduce their tobacco dependence or quit smoking altogether.

Paediatric clinical service delivering critical health needs to Indigenous children

Complex health needs of Indigenous children are being fast-tracked by a unique project designed to reduce red tape and deliver timely paediatric services.