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Research

Excess Mortality Among People With Rheumatic Heart Disease in Australia

Jonathan Carapetis AM AM MBBS FRACP FAFPHM PhD FAHMS Executive Director; Co-Head, Strep A Translation; Co-Founder of REACH 08 6319 1000 contact@

News & Events

OTs and their tools

For Occupational Therapy Week, we asked our OTs to share their favourite resource and how they like to use it.

Research

Clinical Trials in the Brain Tumour Population: Challenges and Strategies for the Future

This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years.

Research

Individual-Level Risk and Resilience Factors Associated with Mental Health in Siblings of Individuals with Neurodevelopmental Conditions: A Network Analysis

Siblings of individuals with neurodevelopmental conditions (NDCs) are exposed to unique family environments and experience a range of psychosocial risk and resilience factors.

News & Events

Service agreements

We are currently working through several clinical audits to ensure that we are meeting our service delivery standards and governance requirements. As part of this, we have audited our Service Agreements to ensure that we have a signed agreement on file for all our clients. This agreement is an NDIS

Research

Harnessing neuroplasticity to improve motor performance in infants with cerebral palsy: A study protocol for the GAME randomised controlled trial

Cerebral palsy (CP) is the most common physical disability of childhood worldwide. Historically the diagnosis was made between 12 and 24 months, meaning data about effective early interventions to improve motor outcomes are scant. In high-income countries, two in three children will walk. This evaluator-blinded randomised controlled trial will investigate the efficacy of an early and sustained Goals-Activity-Motor Enrichment approach to improve motor and cognitive skills in infants with suspected or confirmed CP.

News & Events

Frangipani Family Day 2023

CliniKids held Frangipani Family Day recently – an event organised to honour the wonderful contribution of its much loved and dearly missed colleague, the late Kate Sorensen.

News & Events

Celebrating our OTs

To celebrate World Occupational Therapy (OT) day, we asked our Occupational Therapists to describe what OT means to them.

News & Events

Research at CliniKids

At CliniKids, it is important that the services we offer are informed by the children and families that utilise our services.

Research

Surgery for rheumatic heart disease in the Northern Territory, Australia, 1997-2016: what have we gained?

Between 1964 and 1996, the 10-year survival of patients having valve replacement surgery for rheumatic heart disease (RHD) in the Northern Territory, Australia, was 68%. As medical care has evolved since then, this study aimed to determine whether there has been a corresponding improvement in survival.

News & Events

Autism Month!

April is Autism Month and to mark the occasion, we’re transforming our reception desk in the clinic to an AMAZING wall for our families to contribute to.

Research

Maternal diet modulates the infant microbiome and intestinal Flt3L necessary for dendritic cell development and immunity to respiratory infection

Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell recruitment and perturbation of regulatory T cell expansion in the lungs.

News & Events

Client support at CliniKids

Nicki, Leah, Tracy, and Amy make up our wonderful Client Support team at CliniKids. The team was established in mid-2021 as services began to grow.

Research

Young children's use of blue spaces and the impact on their health, development and environmental awareness: A qualitative study from parents' perspectives

This study examined how families with young children access and use different types of blue spaces and the health and development benefits, and potential negative effects.

Research

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups.

Research

Association of Achieving Time in Range Clinical Targets With Treatment Modality Among Youths With Type 1 Diabetes

Continuous glucose monitoring (CGM) devices have demonstrated efficacy in adults and more recently in youths and older adults with type 1 diabetes. In adults with type 1 diabetes, the use of real-time CGM compared with intermittently scanned CGM was associated with improved glycemic control, but there are limited data available for youths. 

Research

Inter-rater reliability and agreement of the General Movement Assessment and Motor Optimality Score-Revised in a large population-based sample

Prechtl's General Movement Assessment (GMA) at fidgety age (3-5 months) is a widely used tool for early detection of cerebral palsy. Further to GMA classification, detailed assessment of movement patterns at fidgety age is conducted with the Motor Optimality Score-Revised. 

News & Events

Frangipani Family Day a huge success!

CliniKids held its inaugural Frangipani Family Day recently – an event organised to honour the wonderful contribution of its much loved and dearly missed colleague, the late Kate Sorensen.

Our research

As WA's first research collaboration dedicated to mental health, we work across The Kids Research Institute Australia and beyond to do the research that the community wants to see happen.