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Research
Sex assigned at birth may modify health-related quality of life in children treated with peanut oral immunotherapyThe high burden of peanut allergy underscores the need for treatment options that improve patient health-related quality of life (HRQL). However, the modifying effect of sex assigned at birth on treatment-related outcomes remains poorly understood. We sought to investigate whether sex modifies treatment effect on the change in overall and subdomain HRQL during the PPOIT-003 trial.
Two international trials led by The Kids Research Institute Australia’s Neonatal and Infection Immunity Team are tackling the urgent need for simple and safe interventions that can help prevent the adverse long-term effects of infections in extremely preterm babies.
Research
Perspectives on the origin and therapeutic opportunities in Down syndrome-associated leukemiaIt is now well accepted that germline or de novo genetic alterations predispose to cancer development, especially during childhood. Among them, constitutive trisomy 21, also known as Down syndrome (DS), has been shown to predispose to acute leukemia affecting both the myeloid (ML-DS) and lymphoid (DS-ALL) lineages. ML-DS is associated with a good prognosis compared to children without DS, due in part to a higher sensitivity to conventional chemotherapy.
Research
Proteomics confirms immune stabilizing effects of narrowband UVB treatment in patients with clinically isolated syndrome and multiple sclerosisMultiple sclerosis (MS) demonstrates a latitude gradient in prevalence and severity, implicating ultraviolet B (UVB) exposure and photoimmune mechanisms in disease risk and progression. While narrowband (NB)-UVB phototherapy has long stabilized inflammation in dermatology, its systemic immunomodulatory effects in MS remain incompletely defined.
Research
Scalability and scaling-up strategy of a physical activity policy intervention in Australian childcare centresThere is an urgent need for scalable interventions to promote physical activity in early childhood. An early childhood education and care physical activity policy intervention with implementation support strategies (Play Active) has been proposed for scale-up in Australia.
Research
Extreme weather events, home damage, and the eroding locus of controlThe catastrophic consequences of natural disasters on social and economic systems are extensively documented, yet their influence on individuals' sense of control over their life outcomes remains unexplored. This study pioneers an investigation into the causal effects of natural disaster-related home damage on the locus of control.
Research
Vitamin D and SunlightIn a sunny country such as Australia, it’s important to identify how to achieve the right amount of sun exposure for good health. We need to be able to harness the benefits of vitamin D and sunlight while remaining protected from the proven dangers of too much UV radiation.
Research that maps and tracks.
Research
Change in Diet Quality and Dietary Intake From Pregnancy to 1-Year Postpartum: A Longitudinal Analysis in Australian WomenThis longitudinal analysis in Australian women evaluated change in diet quality and food and nutrient intakes from the third trimester of pregnancy to 1-year postpartum with comparison to national nutrition recommendations. Associations between diet quality, sociodemographic and health characteristics were also investigated.
In close partnership with Aboriginal Elders and community members in Western Australia's south-west, we created ‘Kaal Tackles Eczema’, a children’s book to help Aboriginal families manage eczema. Our research showed a high prevalence and need for culturally relevant resources. The book uses Noongar language and art to educate and reduce infections, and is available online and in schools.